Adobe Photoshop.

Here is a picture of two computers sharing some data. I wanted this for use in the web section on drawing exchange using the web nanny. You will see the finished picture deeper in the site. It all starts with a line drawn clip art gif that caught my eye..
First the hands were shaded and color added to the computers. Screen shots were taken of a word document and spreadsheet, then distorted to fit on the monitors (on the source picture you can almost tell what they are working on.).
A backdrop and radiant flare to finish off the whole thing and there you go..